Restoring Self Tolerance to the Immune System to Transform the Treatment of Autoimmune Diseases

Restoring Self Tolerance to the Immune System to Transform the Treatment of Autoimmune Diseases

Restoring Self Tolerance to the Immune System to Transform the Treatment of Autoimmune Diseases

Our Mission

Autoimmune diseases place a staggering toll on our healthcare system and on the lives of patients living with these serious chronic diseases. There are more than 100 different autoimmune diseases, including rheumatoid arthritis, Type 1 diabetes, multiple sclerosis, lupus, Crohn’s disease, and ulcerative colitis.

There is no cure for autoimmune diseases. Currently, available therapies attempt to manage disease symptoms, often relying on immunosuppressive medications that globally dampen immune responses and are burdened with many side effects, which is particularly challenging given the chronic nature of these diseases.

RegCell’s goal is to fundamentally change the way we treat autoimmune diseases by offering therapies that don’t simply address symptoms but provide function and balance to the immune system by restoring long-term immune tolerance in patients with autoimmunity. Our approach is based on the enormous body of work of our scientific founder, Dr. Shimon Sakaguchi.

Dr Sakaguchi is credited with discovering regulatory T cells (Treg) and characterization of their role in maintaining immune tolerance and preventing autoimmune diseases. He has worked extensively to translate this discovery into a therapeutic platform. RegCell’s mission is to utilize this platform to deliver life-changing cell therapies to redefine self-tolerance in patients with autoimmune diseases.

Our Mission

Autoimmune diseases place a staggering toll on our healthcare system and on the lives of patients living with these serious chronic diseases. There are more than 100 different autoimmune diseases, including rheumatoid arthritis, Type 1 diabetes, multiple sclerosis, lupus, Crohn’s disease, and ulcerative colitis.

There is no cure for autoimmune diseases. Currently, available therapies attempt to manage disease symptoms, often relying on immunosuppressive medications that globally dampen immune responses and are burdened with many side effects, which is particularly challenging given the chronic nature of these diseases.

RegCell’s goal is to fundamentally change the way we treat autoimmune diseases by offering therapies that don’t simply address symptoms but provide function and balance to the immune system by restoring long-term immune tolerance in patients with autoimmunity. Our approach is based on the enormous body of work of our scientific founder, Dr. Shimon Sakaguchi.

Dr Sakaguchi is credited with discovering regulatory T cells (Treg) and characterization of their role in maintaining immune tolerance and preventing autoimmune diseases. He has worked extensively to translate this discovery into a therapeutic platform. RegCell’s mission is to utilize this platform to deliver life-changing cell therapies to redefine self-tolerance in patients with autoimmune diseases.

Leadership

Michael McCullar, PhD

Chief Executive Officer

Mike has a wealth of experience in the biotech and pharmaceutical industries, spanning more than two decades.

Steve Kanner, PhD

Chief Scientific Officer (Interim)

Dr Kanner currently serves as our interim chief scientific officer. Until his retirement in June 2025, he served as the chief scientific officer of Caribou Biosciences, Inc.

Kanika Chawla, PhD

Senior Vice President, CMC

Kanika brings deep expertise in process and analytical development, CMC strategy, and technical leadership, spanning early and late-stage development.

Board of Directors

Steve Kanner, PhD

Dr Kanner currently serves as our interim chief scientific officer. Until his retirement in June 2025 he served as the chief scientific officer of Caribou Biosciences, Inc.

Michael McCullar, PhD

CEO RegCell, Inc.

Mike has a wealth of experience in the biotech and pharmaceutical industries, spanning more than two decades.

Jory Bell

Jory has a passion for working with brilliant technical founders who use science and technology to build massive companies that address large-scale societal needs.

Shimon Sakaguchi, MD, PhD

Dr. Sakaguchi is a Distinguished Professor of Osaka University and a member of the US National Academy of Sciences.

Azusa Shiohara, MBA, MSc

Ms. Shiohara is a principal at UTEC where she focuses on biotech and healthcare investments.

Koji Yasuda, PhD, DVM

Dr Yasuda is a principal with Fast Track Initiative (“FTI”).

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